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Nefopam excretion in human milk.
Author(s) -
Liu DT,
Savage JM,
Donnell D
Publication year - 1987
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1987.tb03017.x
Subject(s) - episiotomy , plasma concentration , zoology , medicine , excretion , endocrinology , chemistry , anesthesia , biology , pregnancy , genetics
Human milk and plasma samples were obtained from five healthy nursing mothers who were taking nefopam hydrochloride (60 mg four‐hourly) for post‐episiotomy pain. Concentrations of nefopam were quantified in milk and plasma paired samples, taken daily from birth for 5 days, by a specific paired‐ion reverse phase h.p.l.c. method. Although nefopam was present in human milk in an equivalent concentration to plasma (milk: plasma ratio 1.2 +/‐ 0.7, mean +/‐ s.d.), the likely infant exposure was less than 0.05 mg kg‐1 day‐1 which, on a body weight basis, would be less than 3% of the maternal dose.