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Estimating the clearance of amylobarbitone from a single plasma measurement.
Author(s) -
Bachmann K
Publication year - 1987
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1987.tb03016.x
Subject(s) - chemistry , confidence interval , standard error , liter , volume of distribution , zoology , medicine , statistics , pharmacokinetics , mathematics , biology
Amylobarbitone sodium (200 mg) was given by intravenous injection to nine healthy, young adults (four males). Subjects were drug‐free and nonsmokers. Serial blood samples were drawn for 48 h following the infusion, and multiple sample and single sample estimates of clearance were calculated. The mean (+/‐ s.d.) values for clearance (CL) and apparent volume of distribution (V) were 0.032 (+/‐ 0.007) 1 h‐1 kg‐1 and 1.08 (+/‐ 0.16) 1 kg‐1, respectively. The mean (+/‐ s.d.) single sample estimate of clearance, CL, based on just the 48 h plasma concentrations of amylobarbitone was 0.033 (+/‐ 0.006) 1 h‐1 kg‐1. The 48 h single sample CL value was shown to reliably reflect the value of CL with little bias and good precision. Values of the 48 h CL when compared to CL exhibited a mean prediction error (mpe) of 1.2% with 95% confidence limits of −6.3% to 9.4%, and a root mean squared error (rmse) of 9.4%. It is concluded that amylobarbitone's clearance can be estimated in a single dose, single sample protocol permitting its use as a single dose, single sample probe for studying host factor influences on drug metabolism.