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The effect of an angiotensin converting enzyme inhibitor, ramipril, on bronchial responses to inhaled histamine and bradykinin in asthmatic subjects.
Author(s) -
Dixon CM,
Fuller RW,
Barnes PJ
Publication year - 1987
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1987.tb03015.x
Subject(s) - ramipril , bradykinin , bronchoconstriction , histamine , angiotensin converting enzyme , ace inhibitor , enzyme inhibitor , medicine , pharmacology , endocrinology , asthma , enzyme , chemistry , blood pressure , receptor , biochemistry
The effect of a potent inhibitor of angiotensin‐converting enzyme, ramipril, was studied on both inhaled histamine and bradykinin‐induced bronchoconstriction in six male, normotensive, mild asthmatic subjects. Oral administration of 10 mg ramipril caused no change in lung function or airway reactivity to inhaled histamine or bradykinin despite achieving adequate reduction in angiotensin‐converting enzyme activity.