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Effect of enalapril on the skin response to bradykinin in man.
Author(s) -
Fuller RW,
Warren JB,
McCusker M,
Dollery CT
Publication year - 1987
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1987.tb03014.x
Subject(s) - bradykinin , enalapril , angioedema , angiotensin converting enzyme , pharmacology , in vivo , medicine , placebo , endocrinology , ace inhibitor , enzyme inhibitor , enalaprilat , chemistry , enzyme , biology , biochemistry , blood pressure , receptor , pathology , microbiology and biotechnology , alternative medicine
We tested the effect of oral enalapril on intradermal bradykinin to determine if kininase II inhibition occurs with therapeutic doses in vivo. Six normal male volunteers took either 5 mg enalapril orally or placebo on 2 days. Three hours later bradykinin was injected into the skin of the back in doses increasing from 10(‐11) to 10(‐9) M. Enalapril increased the bradykinin‐induced wheal. Inhibition of kininase II may cause accumulation of endogenous bradykinin. This could be an important mechanism in the occasionally reported side effect of angioedema with the angiotensin converting enzyme (ACE) inhibiting group of drugs.