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Nimodipine disposition and haemodynamic effects in patients with cirrhosis and age‐matched controls.
Author(s) -
Gengo FM,
Fagan SC,
Krol G,
Bernhard H
Publication year - 1987
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1987.tb03008.x
Subject(s) - nimodipine , medicine , anesthesia , cirrhosis , hemodynamics , blood pressure , pharmacokinetics , oral administration , calcium
Six biopsy proven cirrhotics and five age‐matched controls (mean 55.3 vs 52.4 years) were randomly given single 60 mg p.o. and 30 mg s.l. doses of nimodipine. Serum concentrations and blood pressure were measured regularly over the subsequent 24 h period. The clearance of nimodipine was reduced in the patients with cirrhosis. Apparent oral clearance of nimodipine in the cirrhotic group was significantly lower than that observed in the normal group (187 +/‐ 163 l h‐1 vs 469.6 +/‐ 198.4 l h‐1, P less than 0.01). There were no significant changes in mean arterial pressure (MAP) in the normal subjects. There were, however, significant reductions in MAP following oral nimodipine in the cirrhotics. These reductions were significantly related to nimodipine concentrations in individual patients (P less than 0.05).