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The effect of lamotrigine, a novel anticonvulsant, on interictal spikes in patients with epilepsy.
Author(s) -
Jawad S.,
Oxley J.,
Yuen WC,
Richens A.
Publication year - 1986
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1986.tb05249.x
Subject(s) - lamotrigine , anticonvulsant , ictal , epilepsy , diazepam , medicine , placebo , anesthesia , pharmacology , partial epilepsy , psychology , psychiatry , pathology , alternative medicine
Lamotrigine, a novel anticonvulsant, has been evaluated in patients with epilepsy using the method of interictal EEG spike counting. In a randomised double‐blind trial it was found that oral lamotrigine (240 mg) was more effective than placebo, but less effective than diazepam (20 mg) in suppressing interictal spikes. Further clinical evaluation of lamotrigine is recommended in patients with epilepsy.