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Protective effect of theophylline on histamine‐induced bronchoconstriction in asthmatic children.
Author(s) -
Levene S.,
McKenzie SA
Publication year - 1986
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1986.tb05220.x
Subject(s) - bronchoconstriction , theophylline , histamine , placebo , bronchodilator , asthma , medicine , stimulation , anesthesia , pharmacology , endocrinology , alternative medicine , pathology
The bronchial responsiveness of a group of asthmatic children was studied using histamine stimulation after a single dose of theophylline and after placebo. Theophylline, when levels were greater than 10 micrograms ml‐1 significantly reduced responsiveness but only by just over one doubling concentration of histamine (P less than 0.001).