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Racial differences in drug responses‐a comparative study of trimazosin and alpha 1‐adrenoceptor responses in normotensive Caucasians and West Africans.
Author(s) -
Vincent J.,
Elliott HL,
Meredith PA,
Reid JL
Publication year - 1986
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1986.tb05214.x
Subject(s) - medicine , pharmacokinetics , heart rate , blood pressure , placebo , pharmacodynamics , alpha (finance) , endocrinology , essential hypertension , pharmacology , surgery , pathology , construct validity , alternative medicine , patient satisfaction
The possible racial differences in alpha 1‐adrenoceptor responsiveness and the blood pressure and heart rate responses following alpha 1‐ adrenoceptor antagonism with trimazosin have been investigated in matched groups of six Caucasians and six Nigerians. There were no significant differences between the racial groups in the blood pressure and heart rate responses to oral (200 mg) and intravenous (100 mg) trimazosin. alpha 1‐adrenoceptor responsiveness was similar in both groups after placebo and following both active treatments. There were only minor pharmacokinetic differences with the Caucasians having a larger volume of distribution, and a longer terminal elimination half‐ life for the metabolite, 1‐hydroxy‐trimazosin. These results suggest a similarity in peripheral vascular alpha 1‐adrenoceptor mechanisms and show no major significant racial differences in the pharmacokinetics and pharmacodynamics of trimazosin.