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The effect of chloroquine on paracetamol disposition and kinetics.
Author(s) -
AdjeponYamoah KK,
Woolhouse NM,
Prescott LF
Publication year - 1986
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1986.tb05197.x
Subject(s) - chloroquine , cmax , pharmacology , pharmacokinetics , disposition , plasma concentration , kinetics , oral administration , acetaminophen , chemistry , medicine , malaria , immunology , psychology , social psychology , physics , quantum mechanics
The effect of chloroquine on paracetamol kinetics and disposition was investigated in six healthy male Ghanaian volunteers. Chloroquine administration shortened the time taken to reach peak plasma paracetamol concentration (tmax) in five of the volunteers. Peak plasma paracetamol concentration (Cmax) was significantly increased by chloroquine administration. The area under the plasma paracetamol concentration‐time curve was also significantly increased by chloroquine administration. There was, however, no effect of chloroquine on paracetamol metabolism.