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Dose independent pharmacokinetics of mexiletine in healthy volunteers.
Author(s) -
Pringle T.,
Fox J.,
McNeill JA,
Kinney CD,
Liddle J.,
Harron DW,
Shanks RG
Publication year - 1986
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1986.tb05196.x
Subject(s) - mexiletine , pharmacokinetics , volume of distribution , medicine , pharmacology , plasma clearance , plasma concentration , half life , anesthesia
In 12 healthy volunteers who received orally 100, 200, 300, 400 and 600 mg mexiletine at weekly intervals, the maximum plasma concentration of mexiletine and AUC increased linearly with the dose of mexiletine. Between doses there were no significant differences in the values for clearance and volume of distribution of mexiletine but there were for plasma elimination half‐life. These results indicate that the kinetics of mexiletine are linear.