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The effect of intra‐articular steroids on plasma salicylate concentrations.
Author(s) -
Edelman J.,
Potter JM,
Hackett LP
Publication year - 1986
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1986.tb05194.x
Subject(s) - aspirin , sodium salicylate , chemistry , intra articular , glucocorticoid , endocrinology , medicine , salicylic acid , pharmacology , biochemistry , osteoarthritis , pathology , alternative medicine
Plasma salicylate concentrations and salicylate clearances were evaluated in 10 patients before and then 3 days after the intra‐ articular administration of glucocorticoid steroids. All patients were on chronic salicylate treatment, the dosage varying from 1.3‐4.6 g day‐ 1 of enteric‐coated aspirin. The mean steady state plasma concentration (+/‐ s.e. mean) of salicylate decreased significantly after intra‐ articular steroid (90.9 +/‐ 14.8 mg l‐1‐64.7 +/‐ 8.9, P less than 0.05), whilst the mean clearance increased significantly (87.3 +/‐ 20.6 ml min‐1‐120.6 +/‐ 28.3, P less than 0.05). In these paired studies, the intra‐articular administration of steroids lead to a significant decrease in plasma salicylate levels in patients taking enteric‐coated aspirin.