Premium
Abnormal vitamin K metabolism in the presence of normal clotting factor activity in factory workers exposed to 4‐hydroxycoumarins.
Author(s) -
Park BK,
Choonara IA,
Haynes BP,
Breckenridge AM,
Malia RG,
Preston FE
Publication year - 1986
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1986.tb05192.x
Subject(s) - brodifacoum , clotting factor , vitamin , coumarin , medicine , prothrombin time , endocrinology , factor vii , chemistry , anticoagulant , coagulation , organic chemistry
The case histories of two patients exposed to the novel anticoagulants brodifacoum and difenacoum are reported. Abnormal vitamin K1 metabolism, as indicated by elevated vitamin K1 2,3‐epoxide plasma concentrations after i.v. administration of vitamin K1, could be detected for more than 18 months after exposure to the anticoagulants. There was a marked prolongation of prothrombin time (greater than 50 s) in both cases, at the time of exposure. However, subsequent haematological investigations (prothrombin time and vitamin K‐dependent clotting factor activity) have been shown to be normal in both cases for at least 18 months. These cases confirm the long‐acting nature of brodifacoum and difenacoum and present an apparent dissociation between the effect of coumarin anticoagulants on vitamin K1 metabolism and clotting factor activity.