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Does 2‐mercaptoethane sulphonate (mesna) prevent cyclophosphamide and azathioprine induced immunosuppression? In vitro studies.
Author(s) -
AlSafi SA,
Maddocks JL
Publication year - 1986
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1986.tb05189.x
Subject(s) - mesna , azathioprine , immunosuppression , cyclophosphamide , in vitro , pharmacology , medicine , chemistry , immunology , chemotherapy , biochemistry , ifosfamide , disease , etoposide
The effect of 2‐mercaptoethane sulphonate (mesna) on the inhibition of the human MLR by 4‐hydroxycyclophosphamide or azathioprine was studied. 4‐Hydroxycyclophosphamide (34 microM) completely inhibited the MLR and this inhibition was unaffected by 122 microM of 2‐mercaptoethane sulphonate or its disulphide. At high concentrations (mM) 2‐ mercaptoethane sulphonate inhibited the MLR reaching 85% at 24 mM. 2‐ Mercaptoethane sulphonate (15‐122 microM) had no effect on azathioprine (36 microM) inhibition. The results of these in vitro studies suggest that 2‐mercaptoethane sulphonate does not interfere with cyclophosphamide or azathioprine induced suppression of cellular immunity.