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Intravenous adenosine in the treatment of supraventricular tachycardia: a dose‐ranging study and interaction with dipyridamole.
Author(s) -
Watt AH,
Bernard MS,
Webster J.,
Passani SL,
Stephens MR,
Routledge PA
Publication year - 1986
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1986.tb05180.x
Subject(s) - dipyridamole , supraventricular tachycardia , adenosine , dose ranging study , medicine , tachycardia , pharmacology , antiarrhythmic agent , anesthesia , cardiology , heart disease , double blind , alternative medicine , pathology , placebo
Increasing doses of adenosine were given by rapid intravenous bolus to seven patients with spontaneous supraventricular tachycardia. Adenosine restored sinus rhythm in 10 of 14 episodes of narrow complex tachycardia. In those patients in whom adenosine produced only transient ventricular slowing the underlying rhythm was atrial flutter. Transient dyspnoea occurred in all patients. In two patients taking dipyridamole the mean dose of adenosine which produced an electrophysiologic effect (restoration of sinus rhythm or ventricular slowing to under 100 beats min‐1) was 1.0 +/‐ 0.52 mg, whereas in other patients the mean dose was 8.8 +/‐ 2.6 mg, suggesting potentiation of the action of adenosine by dipyridamole.