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Inability of ibuprofen to alter single dose phenytoin disposition.
Author(s) -
Bachmann KA,
Schwartz JI,
Forney RB,
Jauregui L.,
Sullivan TJ
Publication year - 1986
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1986.tb05171.x
Subject(s) - ibuprofen , phenytoin , volume of distribution , free fraction , chemistry , anticonvulsant , medicine , distribution (mathematics) , pharmacokinetics , endocrinology , pharmacology , epilepsy , mathematical analysis , mathematics , psychiatry
The effect of ibuprofen treatment (1600 mg day‐1 per os for 7 days) on single dose (300 mg per os) dispositional parameters of phenytoin (DPH) was evaluated in 10 healthy males. Ibuprofen slightly increased the free fraction of DPH from mean (+/‐ s.d.) value of 6.9 (+/‐ 0.7)% to 7.8 (+/‐ 0.3)% (P less than 0.01). DPH total clearance (CL/F) was not significantly changed going from a value of 0.027 (+/‐ 0.009) 1 h‐1 kg‐ 1 to 0.032 (+/‐ 0.014) 1 h‐1 kg‐1 (0.05 less than P less than 0.1). Intrinsic unbound DPH clearance (CLuint/F) was unaffected by ibuprofen treatment. Neither DPH's apparent volume of distribution (V/F) nor the apparent volume of distribution of unbound DPH (Vunb/F) were significantly altered by ibuprofen treatment. The slight changes in DPH plasma protein binding that are due to concurrent ibuprofen treatment in doses of 1600 mg day‐1 are not likely to produce important changes in DPH dispositional parameters.