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Haemodynamic effects of vasodilating drugs on the common carotid and brachial circulations of patients with essential hypertension.
Author(s) -
Bouthier JD,
Safar ME,
Benetos A.,
Simon AC,
Levenson JA,
Hugues CM
Publication year - 1986
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1986.tb05167.x
Subject(s) - isosorbide dinitrate , medicine , nitrendipine , essential hypertension , captopril , vasodilation , vascular resistance , cardiology , common carotid artery , brachial artery , hemodynamics , pathophysiology of hypertension , anesthesia , blood pressure , carotid arteries
The haemodynamic pattern of the common carotid artery was studied in men with sustained essential hypertension using pulsed Doppler methods before and after administration of vasodilating drugs. Captopril produced both a fall in vascular resistance and an increase in arterial diameter of the common carotid artery. Isosorbide dinitrate increased markedly the arterial diameter but did not change vascular resistance. Nitrendipine decreased vascular resistance with no change in the arterial diameter. In the common carotid circulation of patients with essential hypertension, vasodilating drugs may either dilate small arteries (nitrendipine), large arteries (isosorbide dinitrate), or both (captopril).