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The effect of isoxicam‐aspirin combinations on the polyurethane sponge implantation model in the rat.
Author(s) -
Garrett R,
Manthey B,
VerRoberts B,
Brooks PM
Publication year - 1986
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1986.tb02993.x
Subject(s) - aspirin , sponge , pharmacology , anti inflammatory , inflammation , medicine , chemistry , biology , botany
1 Anti‐inflammatory effects of isoxicam alone and in combination with aspirin were studied in rats using the polyurethane sponge implantation model of acute inflammation. 2 Dose‐response studies were performed to delineate a suppressive (high) and non‐suppressive (low) dose of isoxicam prior to studying these doses in combination with aspirin. 3 The results indicate that a combination of aspirin with isoxicam does not have an additive anti‐inflammatory effect. 4 The interference demonstrated by aspirin with the anti‐inflammatory effects of other NSAIDs such as indomethacin is also demonstrated with aspirin/isoxicam combinations.