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Oxicams: relative safety and anti‐injury effects in rats.
Author(s) -
Whitehouse MW
Publication year - 1986
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1986.tb02990.x
Subject(s) - piroxicam , antipyretic , analgesic , pharmacology , acetaminophen , tenoxicam , detoxification (alternative medicine) , metabolism , irritation , hormone , medicine , drug , drug metabolism , chemistry , endocrinology , immunology , alternative medicine , pathology
1 Oxicams have certain distinctive properties, which distinguish them from other arylalkanoic (carboxylic) acids that show anti‐ inflammatory/analgesic/antipyretic activities. These include: (i) slow rates of metabolism (ii) lesser gastro‐irritancy/ulcerogenicity (iii) preventing fever development (iv) some effect on the adaptive responses of the liver to severe inflammation or trauma that compromise normal hormone/xenobiotic metabolism (detoxification). 2 Isoxicam was notably less gastrotoxic than either piroxicam or tenoxicam, when given either orally or parenterally, at equipotent doses in rats.