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The effects of age on carbamazepine pharmacokinetics and adverse effects.
Author(s) -
Hockings N,
Pall A,
Moody J,
Davidson AV,
Davidson DL
Publication year - 1986
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1986.tb02965.x
Subject(s) - pharmacokinetics , carbamazepine , medicine , psychomotor learning , adverse effect , pharmacology , anesthesia , epilepsy , cognition , psychiatry
The pharmacokinetics and effect of single oral doses of carbamazepine (400 mg) were compared in a group of six young volunteers aged between 20 and 25 years, and a second group of five elderly volunteers aged between 66 and 84 years. No age related changes in salivary or plasma pharmacokinetics or in psychomotor function were detected.