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Pharmacokinetic profile of indoprofen in elderly subjects.
Author(s) -
Lund B,
Egsmose C,
Knudsen O,
Andersen RB
Publication year - 1986
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1986.tb02964.x
Subject(s) - pharmacokinetics , dosing , medicine , osteoarthritis , drug , elderly people , pharmacology , gerontology , alternative medicine , pathology
Multiple dosing four times daily for 7 days of indoprofen 200 mg, a non‐ steroidal anti‐inflammatory drug with a short half‐life (t1/2), revealed drug accumulation in eight elderly subjects. This indicates a substantially longer t1/2 (11 h) than that reported in young persons (3 h). A reduction in dose compared to younger subjects is recommended in elderly patients with osteoarthritis.