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The influence of quinolone derivatives on theophylline clearance.
Author(s) -
Wijnands WJ,
Vree TB,
Herwaarden CL
Publication year - 1986
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1986.tb02957.x
Subject(s) - enoxacin , pefloxacin , theophylline , bronchodilator , pharmacokinetics , pharmacology , ciprofloxacin , drug interaction , metabolite , antibacterial agent , nalidixic acid , bioavailability , medicine , ofloxacin , norfloxacin , oral administration , chemistry , antibiotics , asthma , biochemistry
Enoxacin decreases the metabolic clearance of the bronchodilator theophylline not only in severely ill patients, but also in patients with stable chronic obstructive airways disease. In this comparative study, significantly increased plasma theophylline concentrations were measured during co‐administration of enoxacin (110.9%) and, to a lesser degree, also during co‐administration of pefloxacin (19.6%) and ciprofloxacin (22.8%). Total body clearance of theophylline was significantly decreased by enoxacin (63.6%), ciprofloxacin (30.4%) and pefloxacin (29.4%). The pharmacokinetic parameters of theophylline did not change during co‐administration of ofloxacin and nalidixic acid. There is growing evidence that the observed interaction is caused not by the parent drugs, but by the 4‐oxo metabolite of enoxacin, pefloxacin and ciprofloxacin.