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Sedation for gastroscopy: a comparative study of midazolam and Diazemuls in patients with and without cirrhosis.
Author(s) -
Hamdy NA,
Kennedy HJ,
Nicholl J,
Triger DR
Publication year - 1986
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1986.tb02952.x
Subject(s) - midazolam , sedation , cirrhosis , medicine , anesthesia
A double‐blind controlled study comparing the effects of intravenous Diazemuls (0.15 mg kg‐1) with midazolam (0.07 mg kg‐1) in patients with normal liver function and with cirrhosis and portal hypertension is described. The clinical effect of the two drugs was assessed by serial tests of psychomotor function before and at varying intervals after administration. Using this dosage regime, midazolam caused significantly greater impairment in psychomotor function in both cirrhotic and non cirrhotic subjects, and the time taken for recovery of normal function was also significantly prolonged. Patients with cirrhosis showed a significantly prolonged recovery time following administration of either benzodiazepine compared with the controls. Administration of midazolam in a lower dose might reduce the degree of sedation and shorten the recovery time, but this could also lead to a loss of some of the amnesic effect. Caution is recommended in the administration of benzodiazepines to patients with cirrhosis.