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Salivary concentrations of pirmenol as a possible cause of unpleasant taste.
Author(s) -
Johnson BF,
Shekar V,
Woodman T,
Canada AT
Publication year - 1986
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1986.tb02944.x
Subject(s) - taste , medicine , saliva , endocrinology , wine tasting , plasma concentration , salivary gland , chemistry , food science , wine
Salivary concentrations of the anti‐arrhythmic, pirmenol, were compared with plasma concentrations in six patients. Group mean salivary values tended to be higher despite high plasma protein binding, suggesting the possibility of an active transport process. The observed salivary concentrations are reasonably close to those detectable in healthy volunteers as tasting unpleasant.