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Urinary metabolites of caffeine in pregnant women.
Author(s) -
Scott NR,
Chakraborty J,
Marks V
Publication year - 1986
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1986.tb02920.x
Subject(s) - caffeine , urine , urinary system , excretion , metabolite , endocrinology , medicine , physiology , hormone , pregnancy , biology , genetics
In a study of caffeine and its metabolites in pregnant and non‐pregnant women, on average 56.8% of the administered caffeine dose was recovered in the urine in both groups. However, compared to the controls, the pregnant subjects produced smaller amounts of 1‐methylxanthine and 1‐ methyluric acid, whereas the excretion of most of the other metabolites, particularly 3,7‐dimethylxanthine and 3‐methylxanthine tended to be greater. It is suggested that hormonal influences on the hepatic caffeine metabolising enzymes might be implicated.