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Effect of captopril on changes in plasma noradrenaline induced by sodium nitroprusside.
Author(s) -
Becker RH,
Struthers AD,
Brown MJ
Publication year - 1986
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1986.tb02910.x
Subject(s) - captopril , sodium nitroprusside , medicine , plasma renin activity , endocrinology , renin–angiotensin system , chemistry , pharmacology , sodium , blood pressure , angiotensin ii , nitric oxide , organic chemistry
There is much animal data to suggest that angiotensin II has a regulatory role in noradrenaline release. We sought evidence for such a mechanism in man by pretreating six normal volunteers with captopril (50 mg) or placebo and then infusing them with incremental doses of sodium nitroprusside. Pretreatment with captopril had no significant effect on the mean arterial pressure, heart rate or plasma noradrenaline response to sodium nitroprusside, despite increasing plasma renin activity. This suggests that in normotensive salt replete man, normal levels of angiotensin II do not exert any tonic effect on noradrenaline release.