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Is biliary excretion of paracetamol significant in man?
Author(s) -
Jayasinghe KS,
Roberts CJ,
Read AE
Publication year - 1986
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1986.tb02902.x
Subject(s) - glucuronide , metabolite , excretion , urine , chemistry , acetaminophen , pharmacokinetics , medicine , pharmacology
The extent of biliary excretion of paracetamol and its principal metabolites was studied in 10 healthy adults. Duodenal intubation was performed approximately 12 h after an oral dose of 1 g paracetamol. Duodenal fluid was aspirated following intravenous cholecystokinin, and urine was collected for 12 h after dosing. The mean concentration of the cysteine and glucuronide conjugates in the bile was 253.7 +/‐ 39.0 micrograms ml‐1 (s.e. mean) and 69.3 +/‐ 15.3 micrograms ml‐1, respectively. The mean recoveries of the cysteine and glucuronide conjugates in the bile were 6.0 +/‐ 1.5 mg and 1.2 +/‐ 0.41 mg, respectively. The bile is an important route of elimination for the cysteine conjugate and accounts for 19.4 +/‐ 4.4% of the total excretion of the metabolite. The fate of the biliary excreted conjugates is not known, and needs further investigation.