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Theophylline pharmacokinetics after intravenous infusion with ethylenediamine or sodium glycinate.
Author(s) -
Caldwell J,
Staib AH,
Cotgreave IA,
SiebertWeigel M
Publication year - 1986
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1986.tb02899.x
Subject(s) - theophylline , pharmacokinetics , ethylenediamine , dosing , pharmacology , chemistry , sodium , medicine , inorganic chemistry , organic chemistry
Six healthy volunteers received two theophylline preparations by short intravenous infusion, at weekly intervals in a randomized cross‐over design. The solubilizer was ethylenediamine or sodium glycinate. Plasma concentrations of theophylline and ethylenediamine were measured by h.p.l.c. for up to 24 h after dosing. The pharmacokinetics of theophylline did not show any significant intra‐subject variation associated with the solubilizing agent used.