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The pharmacokinetics of amlodipine in healthy volunteers after single intravenous and oral doses and after 14 repeated oral doses given once daily.
Author(s) -
Faulkner JK,
McGibney D,
Chasseaud LF,
Perry JL,
Taylor IW
Publication year - 1986
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1986.tb02874.x
Subject(s) - pharmacokinetics , half life , volunteer , oral administration , medicine , amlodipine , volume of distribution , pharmacology , oral dose , crossover study , anesthesia , blood pressure , agronomy , biology , alternative medicine , pathology , placebo
Intravenous administration of amlodipine (single dose, 10 mg) to 12 volunteers gave a mean plasma half‐life of 34 h, mean clearance of 7 ml min‐1 kg‐1 and a mean apparent volume of distribution of 21 l kg‐1. Oral administration (single dose, 10 mg) to the same 12 volunteers gave a mean systemic availability of 64% and a mean plasma half‐life of 36 h. In a second study, repeated oral administration (once daily for 14 days, 15 mg) to 28 volunteers resulted in steady state plasma drug concentration being reached after seven doses, an accumulation of approximately threefold and a mean half‐life of 45 h.