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Acute renal effects of doxazosin in man.
Author(s) -
Leeuw PW,
Es PN,
Bos R,
Birkenhager WH
Publication year - 1986
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1986.tb02852.x
Subject(s) - doxazosin , vasoconstriction , medicine , microgram , perfusion , renal blood flow , blood pressure , plasma renin activity , renin–angiotensin system , kidney , endocrinology , renal artery , urology , chemistry , in vitro , biochemistry
To evaluate the role of alpha 1‐adrenoceptors in the regulation of renal blood flow and renin secretion, we infused doxazosin in incremental doses (group I, n = 5) or at a fixed rate of 1 microgram kg‐ 1 min‐1 (group II, n = 6) into the renal artery of hypertensive patients just prior to diagnostic renal angiography. In group I, stepwise increasing doses of doxazosin were associated with increases in renal perfusion and, at doses above 1 microgram kg‐1 min‐1, also with a fall in blood pressure. Compared with observations in control subjects, doxazosin enhanced renal renin release at rest but did not modify the renin response to isometric exercise in group II. alpha 1‐ Adrenoceptors are involved in causing renal vasoconstriction and inhibition of renin secretion. However, the latter is only of importance in resting subjects.