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Transient bradycardia and subsequent sinus tachycardia produced by intravenous adenosine in healthy adult subjects.
Author(s) -
Watt AH,
Routledge PA
Publication year - 1986
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1986.tb02838.x
Subject(s) - bradycardia , adenosine , medicine , sinus bradycardia , heart rate , tachycardia , anesthesia , cardiology , atrioventricular node , sinus tachycardia , bolus (digestion) , sinus (botany) , blood pressure , botany , genus , biology
Adenosine was administered in increasing intravenous bolus doses to nine healthy volunteers. A transient decrease in heart rate was observed which occurred about 20 s after injection. This was due to a reduction in sinus rate and/or transient block of conduction through the atrioventricular node, and lasted less than 10 s. An increase in sinus rate which followed any transient bradycardia was also observed. The maximum bradycardia and maximum tachycardia were each significantly related to the logarithm of adenosine dose.