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A comparison of the pharmacokinetics of propranolol in obese and normal volunteers.
Author(s) -
Bowman SL,
Hudson SA,
Simpson G,
Munro JF,
Clements JA
Publication year - 1986
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1986.tb02837.x
Subject(s) - pharmacokinetics , medicine , propranolol , volume of distribution , oral administration , distribution (mathematics) , obesity , significant difference , mathematical analysis , mathematics
The pharmacokinetics of intravenous and oral propranolol have been compared in six obese and six normal subjects matched for age and sex. After intravenous administration there was no difference in plasma clearance but the volume of distribution was greater (V = 339 l vs 198 l) and the half‐life was longer (t1/2 = 5.0 h vs 3.0 h) in the obese group. No important difference in the rate of oral absorption was observed. A trend towards higher systemic availability in the obese group (35% vs 27%) was not statistically significant.