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Cimetidine absorption in humans during sucralfate coadministration.
Author(s) -
D'Angio R,
Mayersohn M,
Conrad KA,
Bliss M
Publication year - 1986
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1986.tb02834.x
Subject(s) - cimetidine , sucralfate , ingestion , absorption (acoustics) , medicine , pharmacokinetics , pharmacology , oral administration , gastroenterology , materials science , composite material
Cimetidine absorption after a single 300 mg oral dose was evaluated in six normal subjects in the absence or presence of sucralfate. Sucralfate was ingested four times a day for 2 days prior to and for two additional doses on the day of cimetidine ingestion. Sucralfate coadministration had no statistically significant influence on the rate or extent of cimetidine absorption.