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Nicardipine and propranolol in angina pectoris: a comparative study with special reference to ergometer working capacity tests
Author(s) -
BJERLE P.,
OLOFSSON B O.,
GLIMVIK O.
Publication year - 1986
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1986.tb00342.x
Subject(s) - nicardipine , angina , medicine , heart rate , propranolol , blood pressure , placebo , crossover study , rating of perceived exertion , rate pressure product , exertion , bicycle ergometer , cardiology , anesthesia , physical therapy , myocardial infarction , alternative medicine , pathology
1 Patients with stable angina pectoris were studied in a double‐blind crossover trial, comparing the effects of nicardipine (30 mg three times daily) and propranolol (40 mg three times daily) on exercise duration, exercise time without angina, time to 1 mm ST depression, rating of perceived exertion, and systolic blood pressure. 2 Patients underwent bicycle ergometer exercise testing on placebo and before and after each of the treatment periods. 3 There were no significant differences between treatments regarding any of the studied parameters. 4 The ST segment depression/rate pressure product (RPP) ratio was greater after propranolol than nicardipine, suggesting greater efficiency of the heart on nicardipine. 5 The exertion/RPP ratio was lower on nicardipine indicating greater perceived exercise ability.