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Calcium antagonist treatment and its effects on left ventricular function in patients with ischaemic heart disease
Author(s) -
RODRIGUES E. A.,
ALKHAWAJA I. M.,
LAHIRI A.,
RAFTERY E. B.
Publication year - 1986
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1986.tb00339.x
Subject(s) - nicardipine , verapamil , ejection fraction , medicine , cardiology , heart rate , angina , placebo , heart failure , blood pressure , calcium , myocardial infarction , alternative medicine , pathology
1 A double‐blind, cross‐over protocol was used to study the effects of chronic therapy with nicardipine and verapamil on left ventricular function in 21 patients with chronic stable angina. Rest and exercise radionuclide angiography was performed before and after each 4 week treatment period. 2 Resting and exercise heart rates were significantly lower on verapamil than on nicardipine. Rest and exercise systolic blood pressures were not significantly altered by either drug, but peak exercise time increased on both nicardipine and verapamil compared with placebo. 3 Left ventricular ejection fraction and ejection time were comparable on both drugs. Resting ejection rate was unaltered but resting ejection rate index was greater on verapamil than on nicardipine. 4 On exercise, however, ejection rate was significantly higher on nicardipine than on verapamil suggesting improved exercise systolic left ventricular function on nicardipine.