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The effect of nicardipine on pituitary hormone release in normal volunteers.
Author(s) -
Isles TE,
Baty J.,
Dow RJ
Publication year - 1985
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1985.tb05147.x
Subject(s) - nicardipine , prolactin , hormone , endocrinology , medicine , basal (medicine) , placebo , follicle stimulating hormone , pituitary hormones , luteinizing hormone , calcium , alternative medicine , pathology , insulin
In a double‐blind, placebo‐controlled, randomised, cross‐over study of six healthy male subjects, the effect of nicardipine (5 mg h‐1 for 3 h) on basal and stimulated pituitary hormone release was examined. Statistically significant differences between nicardipine and placebo were seen occasionally for follicle‐stimulating hormone, luteinising hormone and prolactin, but not for thyroid‐stimulating hormone. These differences were always within the between‐batch coefficient of variation of the assay. The overall differences in both basal and stimulated results for all four pituitary hormones were not statistically significantly different. It is concluded, therefore, that nicardipine has no significant effect on either basal or stimulated pituitary hormone release in healthy male subjects.