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Nicardipine in models of myocardial infarction.
Author(s) -
Alps BJ,
Calder C.,
Wilson A.
Publication year - 1985
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1985.tb05142.x
Subject(s) - nicardipine , medicine , myocardial infarction , cardiology , coronary occlusion , anesthesia , occlusion , dosing , carnivora , infarction , calcium
In a dog model of partial myocardial ischaemia, superimposed ST segment elevations in epicardial ECGs were inhibited by nicardipine over a cumulative i.v. dose range of 1‐20 micrograms kg‐1. Over the cumulative i.v. dose range of 0.5‐166.5 micrograms kg‐1, nicardipine had little overall effect on gross cardiac conduction, at spontaneous heart rate. Dogs that received oral 1‐2 mg kg‐1 nicardipine daily for 16 weeks and then survived 1 week occlusion of the left anterior descending coronary artery (LAD) developed a superior coronary collateral circulation compared with untreated animals. Nicardipine given by three different dosing schedules to baboons markedly limited myocardial infarction over a 6 h period of LAD occlusion. Compared with a group of completely untreated dogs, there was protection of the myocardium in the animals given nicardipine that survived 3 months occlusion of the LAD.