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Plasma concentrations, information and therapy adherence during long‐ term treatment with antidepressants.
Author(s) -
Altamura AC,
Mauri M.
Publication year - 1985
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1985.tb05137.x
Subject(s) - medicine , antidepressant , drug , pharmacotherapy , coefficient of variation , plasma concentration , psychiatry , statistics , hippocampus , mathematics
The influence of information on drug plasma monitoring during long‐term antidepressant therapy in fourteen ambulant, depressed patients was evaluated as variation in the L/D ratio time course. A larger variability in L/D ratio, with higher coefficient of variation and a poorer clinical outcome, was found in non‐informed patients. The data support the hypothesis that verbal information on long‐term drug monitoring of antidepressants could improve patients' adherence to therapy.