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Lack of effect of nizatidine on hepatic drug metabolism in man.
Author(s) -
Secor JW,
Speeg KV,
Meredith CG,
Johnson RF,
Snowdy P.,
Schenker S.
Publication year - 1985
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1985.tb05136.x
Subject(s) - chlordiazepoxide , pharmacology , lorazepam , theophylline , drug metabolism , glucuronidation , glucuronide , drug , demethylation , metabolism , medicine , drug interaction , disposition , chemistry , antagonist , microsome , receptor , anesthesia , diazepam , enzyme , biochemistry , psychology , social psychology , gene expression , dna methylation , gene
The effect of nizatidine, a new H2‐receptor antagonist, on the hepatic metabolism of three probe drugs was studied in normal volunteers. The drugs studied were chlordiazepoxide and theophylline which are metabolized in part by N‐demethylation by the hepatic microsomal cytochrome P‐450 system and lorazepam which is conjugated to lorazepam glucuronide. A 7 day course of nizatidine did not interfere with the disposition of any of these therapeutic agents in man.