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Amiodarone reduces plasma warfarin clearance in man.
Author(s) -
Watt AH,
Stephens MR,
Buss DC,
Routledge PA
Publication year - 1985
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1985.tb05135.x
Subject(s) - amiodarone , warfarin , drug interaction , pharmacology , mechanism of action , plasma levels , medicine , drug , antiarrhythmic agent , plasma concentration , pharmacokinetics , plasma clearance , clearance , chemistry , atrial fibrillation , heart disease , biochemistry , in vitro , urology
Amiodarone is an effective antiarrhythmic agent whose use is associated with several drug interactions one of which is potentiation of the action of warfarin. The mechanism of this interaction has hitherto been unclear. We examined possible mechanisms in eight patients. Total plasma warfarin clearance was found to be reduced by amiodarone. No change was detected in the binding of warfarin to plasma proteins. No relationship was found between plasma amiodarone concentrations and the change in warfarin clearance.