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Antipyrine clearance and metabolite formation in children with congenital adrenal hyperplasia.
Author(s) -
Teunissen MW,
Bruining GJ,
Jongh BM,
TenkateWesterhof EW,
Breimer DD
Publication year - 1985
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1985.tb05134.x
Subject(s) - congenital adrenal hyperplasia , metabolite , endocrinology , medicine , hyperplasia , metabolic clearance rate , hydrocortisone , physiology , pharmacokinetics
Antipyrine salivary clearance and half‐life and the rate of formation of three principal metabolites of antipyrine (4‐hydroxyantipyrine, 3‐ hydroxymethylantipyrine and norantipyrine) were assessed in nine children with congenital adrenal hyperplasia, six of whom were salt‐ losers and three of whom were non‐salt‐losers. No differences were found in comparison with data obtained in normal children.