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Aminophylline and mucociliary clearance in patients with irreversible airflow limitation.
Author(s) -
Pearson MG,
Ahmad D.,
Chamberlain MJ,
Morgan WK,
Vinitski S.
Publication year - 1985
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1985.tb05130.x
Subject(s) - aminophylline , mucociliary clearance , medicine , anesthesia , airflow , lung , mechanical engineering , engineering
Were aminophylline to improve mucociliary function, it might prove useful in the management of irreversible airflow limitation. Eight subjects with irreversible airflow limitation due to emphysema inhaled an aerosol of 99mTc sulphur‐colloid particles on each of 2 days. On day 1 aminophylline was administered intravenously, while on the other nothing was given. Particle clearance was measured by recording posterior gamma‐camera images sequentially over a 24 h period. No significant differences were recorded between aminophylline and control studies, but there were marked variations in clearance between study days and between individuals. These differences were compatible with the known effects of airways obstruction and breathing pattern on the sites of particle deposition within the bronchial tree. The latter factors appeared to exert a far greater influence on the observed mucociliary clearance than did aminophylline.