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No effect of ethanol ingestion on beta‐adrenoceptor‐mediated circulatory responses to isoprenaline in man.
Author(s) -
Eisenhofer G.,
Lambie DG,
Johnson RH
Publication year - 1985
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1985.tb05129.x
Subject(s) - isoprenaline , heart rate , ingestion , atropine , circulatory system , blood pressure , ethanol , medicine , endocrinology , bolus (digestion) , anesthesia , chemistry , biochemistry , stimulation
The acute effects of ethanol on circulatory responses to isoprenaline and atropine were investigated in 21 and 15 normal male subjects respectively. Each subject acted as his own control by participating twice, once after consumption of ethanol (1.0 ml kg‐1, 20% v/v in orange juice) and once after orange juice. Ethanol increased baseline heart rate and forearm blood flow, but had no effect on heart rate and forearm blood flow responses to isoprenaline, or on heart rate responses to atropine. Baseline blood pressure and blood pressure responses to isoprenaline were also unaffected by ethanol. It is concluded that acute ethanol ingestion has no physiologically significant effect on beta‐adrenoceptor responsiveness as assessed by the cardiovascular responses to bolus doses of isoprenaline.