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A comparison of the cardiovascular effects of (+)‐sotalol and (+/‐)‐ sotalol following intravenous administration in normal volunteers.
Author(s) -
Johnston GD,
Finch MB,
McNeill JA,
Shanks RG
Publication year - 1985
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1985.tb05109.x
Subject(s) - sotalol , qt interval , medicine , placebo , repolarization , anesthesia , pharmacology , cardiology , electrophysiology , atrial fibrillation , alternative medicine , pathology
In a placebo controlled open study in six healthy male volunteers (+)‐ sotalol in the dose range 0.125 mg kg‐1‐2.0 mg kg‐1 intravenously, was found to have little or no beta‐adrenoceptor blocking activity in comparison to the racemic mixture (+/‐)‐sotalol. The repolarization effects of (+)‐ and (+/‐)‐sotalol on the QTc interval however were comparable over the same dose range. The beta‐adrenoceptor blocking activity and repolarization effects of sotalol appear to be unrelated.