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Determinants of plasma alpha 1‐acid glycoprotein (AAG) concentrations in health.
Author(s) -
Blain PG,
Mucklow JC,
Rawlins MD,
Roberts DF,
Routledge PA,
Shand DG
Publication year - 1985
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1985.tb05107.x
Subject(s) - orosomucoid , alpha (finance) , glycoprotein , chemistry , pharmacology , biochemistry , medicine , psychometrics , clinical psychology , construct validity
The concentration of alpha 1‐acid glycoprotein (AAG) was measured in plasma from 200 healthy subjects belonging to 78 family units. The AAG concentration varied markedly between individuals (mean 0.77, range 0.36‐1.46 g 1(‐1]. When the genetic contribution to the variability was assessed, the only significant correlation observed was that between husband and wife and this was weak. We conclude that in addition to the known effects of age and gender, environmental (rather than genetic) factors largely determine the variance of AAG concentrations.