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Enhanced weal and flare response to histamine in chronic idiopathic urticaria.
Author(s) -
Krause LB,
Shuster S.
Publication year - 1985
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1985.tb05103.x
Subject(s) - histamine , medicine , potency , flare , chronic idiopathic urticaria , endocrinology , chronic urticaria , chemistry , biochemistry , astrophysics , in vitro , physics
Weal and flare histamine dose‐responses were measured in 30 normal subjects and 15 patients with chronic idiopathic urticaria. The log dose‐response curves were shifted to the left corresponding to an increase in histamine potency of 2.5 for weal and 3.1 for flare. An enhanced response to histamine may be important in chronic idiopathic urticaria and comparison of potency of antihistamines in different subjects may be unreliable where initial weal response is abnormal.