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Stereoselective disposition of indoprofen in surgical patients.
Author(s) -
Bjorkman S.
Publication year - 1985
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1985.tb05098.x
Subject(s) - enantiomer , volume of distribution , pharmacokinetics , stereoselectivity , distribution (mathematics) , pharmacology , medicine , anesthesia , disposition , half life , chemistry , stereochemistry , mathematics , psychology , mathematical analysis , social psychology , biochemistry , catalysis
The pharmacokinetics of the enantiomers of indoprofen were determined after intravenous administration of the racemate to 10 surgical patients. The mean volume of distribution was 8.97 +/‐ 2.21 (s.d.) 1 for the pharmacologically active S(+)‐enantiomer and 12.60 +/‐ 4.21 1 for the R(−)−enantiomer (P less than 0.001). The corresponding values for clearance were 32.2 +/‐ 11.1 ml min‐1 and 48.8 +/‐ 15.5 ml min‐1 (P less than 0.001). There was no significant difference in mean terminal half‐life between the enantiomers.