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The effect of ultrasound on the percutaneous absorption of lignocaine.
Author(s) -
McElnay JC,
Matthews MP,
Harland R.,
McCafferty DF
Publication year - 1985
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1985.tb05089.x
Subject(s) - phonophoresis , ultrasound , medicine , percutaneous , anesthesia , surgery , radiology
The influence of ultrasound on the percutaneous absorption of lignocaine from a cream base was investigated in a double‐blind cross‐ over trial in healthy volunteers. Mean data indicated that there was a slightly faster onset time for local anaesthesia when ultrasound was administered when compared with control values (no ultrasound). However, the differences were not statistically significant. Further controlled clinical studies are required into the effect of ultrasound on percutaneous absorption since the technique (phonophoresis) has been alleged to enhance percutaneous penetration of a number of drugs.