Premium
The influence of ranitidine, alone and in combination with clemastine, on histamine‐mediated cutaneous weal and flare reactions in human skin.
Author(s) -
Thomas RH,
Browne PD,
Kirby JD
Publication year - 1985
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1985.tb05080.x
Subject(s) - ranitidine , histamine , cimetidine , pharmacology , metiamide , histamine h1 receptor , stimulation , thioperamide , histamine h2 receptor , chemistry , in vivo , histamine receptor , receptor , medicine , endocrinology , antagonist , biology , microbiology and biotechnology
Significant, (P less than 0.05) inhibition of histamine induced cutaneous weal and flare reactions by ranitidine at 10(‐5) M concentration has been demonstrated in a double blind, in vivo study; the results support the evidence for cutaneous H2‐histamine receptors provided by previous studies using cimetidine and metiamide. The degree of inhibition of histamine mediated cutaneous reactions achieved by clemastine was increased by the administration of clemastine and ranitidine together, for ranitidine concentrations 10(‐5) M (P less than 0.001) and 10(‐6) M (P less than 0.05). The magnitude of the inhibitory effect of ranitidine, both administered alone and in combination with clemastine, suggests that in the production of histamine induced cutaneous weal and flare reactions, the contribution afforded by stimulation of cutaneous H2‐histamine receptors is only small.