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Effect of short surgical procedures on salivary paracetamol elimination.
Author(s) -
Ray K.,
Adithan C.,
Bapna JS,
Kangle PR,
Ray K.,
Ramakrishnan S.
Publication year - 1985
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1985.tb05054.x
Subject(s) - medicine , anesthesia , saliva , acetaminophen , surgery , analgesic , surgical procedures , pharmacokinetics
The effect of short surgical procedures on paracetamol elimination was studied in seven male patients undergoing surgery with epidural anaesthesia. Five healthy volunteers who did not undergo surgery served as a control group. Paracetamol concentration was measured in saliva at various intervals 1 day before and after surgery. Paracetamol half‐life (t1/2,z) decreased and metabolic clearance rate (CL) increased after surgery as compared to preoperative values. The results suggest that surgical stress may enhance the hepatic metabolism of paracetamol.