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Effects of single and multiple doses of ketoconazole on adrenal function in normal subjects.
Author(s) -
Bradbrook ID,
Gillies HC,
Morrison PJ,
Robinson J.,
Rogers HJ,
Spector RG
Publication year - 1985
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1985.tb05051.x
Subject(s) - ketoconazole , discontinuation , cosyntropin , medicine , adrenal function , oral dose , endocrinology , intramuscular injection , pharmacology , hydrocortisone , pharmacokinetics , oral administration , adrenocorticotropic hormone , hormone , antifungal , dermatology
The plasma cortisol response to 0.25 mg tetracosactrin given by intramuscular injection was suppressed by nine oral doses of 200 mg ketoconazole given 12 hourly to nine normal female subjects. No effect was noted following a single 200 mg oral dose of ketoconazole. This suppressive effect was reversible within at least 5 days of discontinuation of ketoconazole.